Contact Dr. Lindquist for consultation 1-800-838-4268 or
Skip to main content

Feline Splenic Plasmacytoma

Patient Information

10 Years
Male, Neutered



Feline Splenic Plasmacytoma.
Images by Marty Henderson DVM ( “Checkers”

History (Henderson): A 10-year-old MN DLH cat presented for vomiting, depression, weakness, and “not quite himself.” Clinical exam findings were uneventful. The complete blood count revealed anemia (PCV 16% - 3+ anisocytosis, 2+ polychromasia, 2+ rouleaux present), neutropenia 1659 (n 2500-8500) and lymphocytopenia 273 (n 1200-8000). Blood chemistry revealed slightly elevated total bilirubin, which may have been laboratory error (0.9 mg/dl).

Clinical Differential Diagnosis

(Frank): Regenerative anemia - IMHA and blood loss. However a reticulocyte count would be necessary to confirm a regenerative process. Given the presence of concurrent neutropenia and the absence of overt infection, lack of production or increased destruction by the bone marrow is likely and could also reflect the source of the anemia. Therefore other differentials include primary bone marrow disease (especially if the anemia is actually non-regenerative) such as aplastic anemia, myelofibrosis, myelodysplasia, myeloproliferative disease/ hemopoetic neoplasia, mast cell disease, lymphoma, FeLV infection, as well as other infectious diseases such as various vector borne diseases (Mycoplasma, ehrlichiosis etc).

Image Interpretation

(Yanik/Lindquist): Virtual convex linear video clip of a feline spleen with mild, uniform splenic enlargement (approximately 1.3 cm in width). The parenchyma demonstrates a subtle mottled to micronodular changes and slight heterogenicity consistent with a "honeycomb" appearance.

Sonographic Differential Diagnosis

(Yanik/Lindquist): Early infiltration in with round cell neoplasia (lymphoma, mast cell disease, multiple myeloma) is strongly suspected, especially if clinical signs are consistent with these disease processes. Reactive hyperplasia or equivalent benign pathology is a lesser possibility


Bone marrow biopsy would have been necessary to explain the anemia and neutropenia but was declined by the owner.